MD is a lymphomatous and neuropathic disease of domestic birds caused by an alphaherpesvirus. Fowls get infected by inhalation of infected dust from the poultry houses and the virus is shed from the feather follicle of infected birds. Chickens are the most important natural hosts for MD which usually takes place at 1230 weeks of age. Besides MD is one of the most ubiquitous avian infections. It has been reported in chicken flocks worldwide. Every flock except those maintained under strict path